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Loss of integrin recycling via Arf6 knockout disrupts lumen biogenesis. Representative endothelial cell sprout treated with scramble (Scram) siRNA (si) or Arf6 si and stained for podocalyxin (Podxl) and actin localization. Note the absence of a luminal cavity upon disruption of integrin signaling via Arf6 knockdown. The white boxes represent areas of magnification. Dotted lines are sprout boundaries. L lumen
