Table 1.
Rab GTPase’s regulators, effectors and function
| Rab GTPase | GEF(s) | GAP(s) | Effector | Function | Citations |
|---|---|---|---|---|---|
| Rab1a/b | TRAPP I, DrrA | TBC1D20 | – | ER to Golgi trafficking | Lamber et al., Current Opinions in Cell Biology, 2019 |
| Rab2b | – | – | Bicaudal-D, RUND-1, CCCP-1 | ER to Golgi trafficking | Zhen et al., Journal of Cell Science, 2015; Ailion et al., Neuron, 2014 |
| Rab3d | – | – | – | WPB localization | Zografou et al., Journal of Cell Science, 2012 |
| Rab4a/b | – | TBC1D11, EVI5-like | Rabip4, Rabaptin-5, RabEP2 | Early-endosome trafficking | Stein et al., Advanced Drug Delivery Reviews, 2003; Zografou et al., Journal of Cell Science, 2012 |
| Rab5a/b/c | Rabex-5 (Vps9),, Rabaptin-5 | TBC1D3/RUTBC3/USP6NL | EEA1, RIN2 | Early-endosome trafficking, podxl trafficking in epithelium | Stein et al., Advanced Drug Delivery Reviews, 2003; Richards et al., Current Biology, 2015 |
| Rab6 | RIC1-RGP1 | – | Bicaudal-D | Golgi-localized trafficking | Lamber et al., Current Opinions in Cell Biology, 2019; Zhen et al., Journal of Cell Science, 2015 |
| Rab7 | MON1-CCZ1 | TBC1D5 | RILP, VPS34, HOPS | Lysosome transport | Lamber et al., Current Opinions in Cell Biology, 2019; Stein et al., Advanced Drug Delivery Reviews, 2003; Zhen et al., Journal of Cell Science, 2015 |
| Rab8a | Rabin-8/GRAB/Mss450/C9Orf72 | TBC1D1/TBC1D30/TBC1D4 | – | TGN trafficking | Müller et al., Small GTPases, 2018 |
| Rab9 | – | – | RUTBC1, RUTBC2 | Late endosome | Zhen et al., Journal of Cell Science, 2015 |
| Rab10 | DENND4c | TBC1D1/TBC1D4/EVI5-L | Basolateral trafficking | Gross et al., Angiogenesis, 2021 | |
| Rab11a/b | SH3BP5 (REI-1)/SH3BP5 (REI-1) | TBC1D11/TBC1D15/EVI5, TBC1D14 | Rip11, RCP, Eferin, Protrudin | Endocytic uptake and recycling | Stein et al., Advanced Drug Delivery Reviews, 2003; Zhen et al., Journal of Cell Science, 2015 |
| Rab13 | DENND1c | TBC1D10A, TBC1D25 | – | Tubular endosome, TGN trafficking | Müller et al., Small GTPases, 2018; Homm, et al., The FEBS Journal, 2021 |
| Rab14 | DENND6 | TBC1D1 | – | Early endosome trafficking | Müller et al., Small GTPases, 2018; Homma et al., The FEBS Journal, 2021 |
| Rab15 | – | – | – | WPB localization, endosomes in other tissues | Zografou et al., Journal of Cell Science, 2012 |
| Rab21 | – | – | Protein tyrosine phosphatase receptor type F (PTPRF) | Endocytosis of integrins bound to fibronectin | Mana et al., Nature Communications, 2016 |
| Rab25 | – | – | – | Podxl trafficking in epithelium | Richards et al., Current Biology, 2015 |
| Rab 27 | MADD/DENN/Rab3GEP | TBC1D10A/EPI64/Rab27‐GAPα, TBC1D10B/FLJ13130 | Slp2a, MYRIP, Slp4a | WPB negative regulator | Francis et al., ATVB, 2021; Fukuda et al., Traffic, 2013 |
| Rab33 | RIC1-RGP1 | RUTBC1, RUTBC2 | – | – | Lamber et al., Current Opinions in Cell Biology, 2019; Zografou et al., Journal of Cell Science, 2012 |
| Rab35 | DENND1a/DENND1b/DENND1c | TBC1D10A/TBC1D10B/TBC1D10C/TBC1D13/TBC1D24 | ACAP2, RUSC2, OCRL, MICAL-L1 | Plasma membrane endocytosis, cytoskeletal re-arrangements | Chaineau et al., Traffic, 2013; Marat et al., Molecular Biology of the Cell, 2012 |
| Rab37 | – | – | – | WPB localization | Zografou et al., Journal of Cell Science, 2012 |
| Rab46 | – | – | – | WPB localization | Miteva et al., Journal of Cell Biology, 2019 |
Podxl Podocalyxin, WPB Weibel–Palade body, TGN trans-Golgi network