Table 2.
Pharmacokinetic parameter estimates for the final ceftriaxone pharmacokinetic model
| Parameter | Mean ± SD | CV (%) | Median |
|---|---|---|---|
| CLr (L/h) | 0.90 ± 0.47 | 52.58 | 1.00 |
| CLnr (L/h) | 0.33 ± 0.24 | 70.84 | 0.19 |
| CLrrt (L/h) | 0.85 ± 0.49 | 57.64 | 0.89 |
| Vc (L) | 7.94 ± 1.93 | 24.31 | 7.82 |
| kCP (h−1) | 1.94 ± 2.60 | 134.24 | 0.92 |
| kPC (h−1) | 0.77 ± 0.55 | 71.99 | 0.67 |
| kon (h−1) | 4.97 ± 4.61 | 21.28 | 3.08 |
| koff (h−1) | 20,397.60 ± 5359.50 | 28,724,219.86 | 19,840.04 |
| β | 1.39 ± 0.43 | 0.18 | 1.52 |
β number of ceftriaxone binding sites per albumin molecule, CLnr ceftriaxone non-renal clearance, CLr ceftriaxone renal clearance, CLrrt ceftriaxone dialytic and residual clearance, CV coefficient of variation, kCP constant for distribution of ceftriaxone from the central to the peripheral compartment, koff constant for ceftriaxone disassociation affinity off albumin, kon constant for ceftriaxone binding affinity onto albumin, kPC constant for distribution of ceftriaxone from the peripheral to the central compartment, SD standard deviation, Vc volume of distribution of the central compartment