Fig. 10. T cell Abca1/Abcg1 deficiency induces T cell apoptosis and T cell senescence in middle-aged mice.
(1) T cell Abca1/Abcg1 deficiency increases T cell activation, leading to (2) T cell apoptosis and (3) decreases in peripheral T cells and interferon gamma (IFN-γ) secretion. Consequently, in middle-aged mice, T cell Abca1/Abcg1 deficiency decreases (4) aortic inflammation leading to (5) a decrease in atherosclerotic lesion area. (6) T cell Abca1/Abcg1 deficiency induces cellular senescence in middle-aged mice. TCR, T cell receptor.