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. 2022 Jul 1;12:11189. doi: 10.1038/s41598-022-14721-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Functional classification of the 74 genes of interest. Using the PANTHER Classification System (17.0)⁵⁸ showed that 65% of the 74 aforementioned genes have a catalytic function, which relates to the underlying metabolic modelling to TISMAN. A functional enrichment analysis performed in STRING v11⁵⁷ identified oxidase and ligase activity in lipid metabolism to be particularly prevalent in this gene list.