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. 2022 Jul 1;12:11119. doi: 10.1038/s41598-022-14432-2

Table 6.

The incidence of complications during hospitalization in ELBW infants.

 < 500 g (n = 22) 500–599 g (n = 52) 600–699 g (n = 150) 700–799 g (n = 372) 800–899 g (n = 685) 900–999 g (n = 1294) Total (n = 2575) p-value*
RDS
Assessed, n 22 52 150 372 685 1294 2575
Diagnosed, n (%) 21 (95.5) 46 (88.5) 141 (94.0) 331 (89.0) 579 (84.5) 1075 (83.1) 2193 (85.2)  < 0.001
Oxygen dependency at 28 days
Assessed, n 5 18 58 140 360 821 1402
Diagnosed, n (%) 5 (100.0) 16 (88.9) 46 (79.3) 111 (79.3) 249 (69.2) 466 (56.8) 893 (63.7)  < 0.001
ROP
Assessed, n 5 22 71 187 412 819 1516
Diagnosed (any grade), n (%) 1 (20.0) 10 (45.5) 32 (45.1) 77 (41.2) 155 (37.6) 321 (39.2) 596 (39.3) NS
Diagnosed (≥ grade 3), n (%) 0 8 (36.4) 10 (14.1) 29 (15.5) 44 (10.7) 62 (7.6) 153 (10.1)  < 0.001
NEC
Assessed, n 12 38 102 242 508 1074 1976
Diagnosed (any stage), n (%) 0 6 (15.8) 19 (18.6) 32 (13.2) 52 (10.2) 128 (11.9) 237 (12.0) NS
Diagnosed (≥ stage IIb), n (%) 0 1 (2.6) 5 (4.9) 5 (2.1) 15 (3.0) 21 (2.0) 47 (2.4) NS
IVH
Assessed, n 12 38 92 252 493 958 1845
Diagnosed (any grade), n (%) 8 (66.7) 15 (39.5) 38 (41.3) 95 (37.7) 140 (28.4) 246 (25.7) 542 (29.4)  < 0.001
Diagnosed (≥ grade III), n (%) 6 (50.0) 6 (15.8) 16 (17.4) 32 (12.7) 33 (6.7) 51 (5.3) 144 (7.8)  < 0.001
PVL
Assessed, n 12 38 92 252 493 958 1845
Diagnosed, n (%) 0 (0) 1 (2.6) 5 (5.4) 20 (7.9) 45 (9.1) 77 (8.0) 148 (8.0) NS

RDS, respiratory distress syndrome; ROP, retinopathy of prematurity; NEC, necrotizing enterocolitis; IVH, intraventricular hemorrhage; PVL, periventricular leukomalacia; NS, no significant difference.

*Chi-square test linear-by-linear association were used to compare the groups of 500–599 g, 600–699 g, 700–799 g, 800–899 g and 900–999 g.