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. 2022 Jul 1;13:3808. doi: 10.1038/s41467-022-31501-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Left: heatmaps and histograms of Scr_T1 > Ubx_T3, Scr_T1 ≈ Ubx_T3 and Scr_T1 < Ubx_T3 loci plotted for Scr_T1 and Ubx_T3 ChIPs signals. Right: blow-up of the 432 Scr_T1 > Ubx_T3 and 62 Scr_T1 < Ubx_T3 loci. Loci in each of the three classes are sorted by the FDR values generated by DiffBind in ascending order (see “Methods” for details). The loci are aligned at the peak center, with +/−1 kb shown. In all heatmaps in this and other panels, the color intensity scores are arbitrary values indicating relative TF occupancy at the target locus. b Bar graph showing the genome region classification of Scr_T1 > Ubx_T3, Scr_T1 ≈ Ubx_T3 and Scr_T1 < Ubx_T3 loci. c Scatter plots comparing T1 and T3 chromatin accessibility in Scr_T1 > Ubx_T3 (left), Scr_T1 ≈ Ubx_T3 (middle) and Scr_T1 < Ubx_T3 (right) loci. The size of a dot represents the average of Scr_T1 and Ubx_T3 ChIP signals at that locus, and the color indicates the log2 ratio between Scr_T1 and Ubx_T3 ChIP-seq signals. d, e Histograms showing relative affinity scores using NRLB models for Scr and Ubx monomers (d), and Scr-Exd and Ubx-Exd heterodimers (e) in Scr_T1 > Ubx_T3 (red) and Scr_T1 ≈ Ubx_T3 (black) loci +/−1 kb relative to the peak center.