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. 2022 Jul 1;12:11200. doi: 10.1038/s41598-022-15234-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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High levels of LGR5 expression in the fallopian tubes. (A) Ampulla of the fallopian tube harbors two types of epithelial cells: ciliated cells (indicated by yellow arrowheads) and secretory cells (indicated by red arrowheads). Strong LGR5 expression seems to be confined to secretory cells. Scale bar, 0.5 mm (left panel) and 50 µm (middle and right panels). (B) The epithelium in the fimbria exhibits the same LGR5 expression pattern as in the ampulla. Scale bar, 0.5 mm (left panel) and 50 µm (middle and right panels). Combined in situ hybridization for LGR5 (white dots) and multiplex immunohistochemistry for PAX8 (red nuclear stain) and FOXJ1 (green nuclear stain) was performed on a ciliated cell-rich area (C) and on a secretory cell-rich area (D). PAX8-positive secretory cells display strong LGR5 expression (indicated by red arrowheads), while FOXJ1-positive ciliated cells do not express LGR5 (indicated by yellow arrowheads). (E) A bar graph showing that histo-scores (H-scores) of LGR5 are much higher in fallopian tubes than in ovaries. OSE in R, ovary surface epithelium in regeneration. The data are shown as the means ± SD. ns not significant. **P < 0.01 by Tukey’s multiple comparisons test.