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. 2022 Jul 1;12:11200. doi: 10.1038/s41598-022-15234-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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LGR5 expression in various histological subtypes of ovarian carcinomas. Representative images of LGR5 expression in mucinous carcinoma (MC, n = 44) (A), endometrioid carcinoma (EC, n = 47) (B), and clear cell carcinomas (CCC, n = 48) (C). Scatter plots showing histo-scores (H-scores) of epithelial (D) or stromal (E) LGR5 expression in each subtype of ovarian carcinoma. (F) A bar graph showing the proportions of epithelial and stromal LGR5 positivity in each subtype of ovarian carcinomas with an H-score cutoff value of 40. Low-grade serous carcinoma (LGSC, n = 12), High-grade serous carcinoma (HGSC, n = 64). Scale bar, 0.2 mm (left two panels) and 50 µm (right two panels) (A,C); 0.2 mm (upper panels) and 50 µm (lower panels) (B). ns not significant. **P < 0.01, ***P < 0.001, ****P < 0.0001 by Tukey’s multiple comparisons test.