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. 2022 Jul 1;5:646. doi: 10.1038/s42003-022-03582-8

Fig. 5. A proposed model showing how conserved cysteines in HGF PAN domain determines the fate of c-MET signaling cascade.

Fig. 5

PAN domain provides the catalytic core to HGF for c-MET interaction leading towards initiation of the entire downstream HGF/c-MET axis. Alteration in conserved cysteine residues blocks the activation of several transcription factors and effector molecules which otherwise stimulate cell migration, cell invasion, proliferation, and cell motility. Figure created with BioRender.com.