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. 2022 Mar 28;11(13):2627–2643. doi: 10.1002/cam4.4638

FIGURE 6.

FIGURE 6

Upregulation of exosomal miR‐16‐5p in cell culture medium restrained the tumor growth by the suppression of the PD‐L1 level. (A) The relative PD‐L1 protein expression in the HCC827 cells by WB detection. ** vs. Vector (NC Vector), p < 0.01. (B) The exosomal miR‐16‐5p expression in the HCC827 cell culture medium by qRT‐PCR. * vs. Vector (NC Vector), p < 0.05. (C‐D) Tumor volume and weight of the xenograft tumor tissues in nude mice. * vs. Vector (NC Vector), p < 0.05; ** vs. Vector (NC Vector), p < 0.01; # vs. pcDNA‐PD‐L1, p < 0.05. (E) The relative PD‐L1 protein expression in xenograft tumor tissues from nude mice by WB. *** vs. NC Vector (Vector), p < 0.001; ## vs. pcDNA‐PD‐L1, p < 0.01. PD‐L1, programmed cell death ligand‐1; NC, negative control