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ROC of the baseline (“base”) versus multi-task learning (“mtl”) models. a: The multi-task learning model better discriminates between GOF and LOF variants. b: One-versus-one ROC curves for the baseline model. c: One-versus-one ROC curves for the multi-task learning model. Abbreviations: AU-ROC – area under the receiver operating characteristic; GOF – gain-of-function; LOF – loss-of-function.
