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. 2022 Jun 24;81:104115. doi: 10.1016/j.ebiom.2022.104115

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

SHAP (SHapley Additive exPlanations) contribution plots and feature importance. Shapley values are the average expected marginal contribution for each feature after all possible feature combinations have been considered. a: Mean Shapley values for GOF variants. b: Mean Shapley values for LOF variants. c: Mean Shapley values for neutral variants. Contribution may either be positive (green) or negative (red). d: Mean absolute Shapley values for all classes. Feature abbreviations are shown in brackets, with additional information available in Supplementary Table 1.