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. Author manuscript; available in PMC: 2022 Oct 27.
Published in final edited form as: Nat Biomed Eng. 2022 Apr 27;6(4):351–371. doi: 10.1038/s41551-022-00882-6

Extended Data Figure 7 |. Proteomic breakdown of bone, liver, and skin tissues studied over four weeks in (i) InterOrgan multi-tissue platform, (ii) in the Mixed media approach, and (iii) in Isolation.

Extended Data Figure 7 |

a-c, Proteomic breakdown of engineered bone (6,000+ unique proteins; a), liver (2,000+ proteins; b), and skin (2,000+ proteins; c) studied over 28 days in the (i) integrated InterOrgan multi-tissue platform, (ii) platform with mixed media, and (iii) tissues cultured in isolation. Comparison of integrated versus mixed conditions via differential protein abundances is represented by Volcano plots. d-f, PGSEA plots of the top 30 GO Biological Process pathways, with red indicating activated pathways and blue indicating suppressed pathways for bone (d), liver (e), and skin (f). g, Immunohistochemical staining for picrosirius red details collagen within liver, skin and bone tissues after 28 days.