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. Author manuscript; available in PMC: 2022 Jul 2.
Published in final edited form as: Nature. 2022 Apr 20;605(7908):139–145. doi: 10.1038/s41586-022-04632-1

Figure 1. Characterization of tumor-infiltrating CD8+ T cells.

Figure 1.

a, Uniform manifold approximation and projection (UMAP) of CD45+TCRβ+CD8α+ lymphocytes in breast tumor tissues from PyMT mice. Clusters (C) are denoted by color. b, Violin plots comparing expression of signature genes of indicated clusters. c, Three-dimensional diffusion embedding generated using clusters C1-C5 cells. d, Visualization of diffusion component (DC) analysis comparing the gene expression programs of cells from C2-C5 to that of C1 cells. e, Diffusion distance from C2-C5 cells to C1 cells. Statistical differences between the distribution of diffusion distances for each pair of clusters were calculated using a two-sided Wilcoxon test with P < 2.2e-16 between C2 and C4, C2 and C3, and C2 and C5.