TABLE 2.
Tissue | Protein | Ames gene effect (no GH) | GH effect (in Ames mice) |
---|---|---|---|
BAT | UCP1 | 1.89, p < .0001 | 0.66, p = .0002 |
BAT | iNOS | 0.72, p = .008 | 1.23, p = .21 |
BAT | ARG1 | 2.2, p < .0001 | 0.66, p = .01 |
BAT | GPLD1 | 1.93, p < .0002 | 0.65, p = .007 |
Inguinal fat | UCP1 | 1.79, p = .001 | 0.60, p = .005 |
Inguinal fat | iNOS | 0.60, p = .18 | 1.67, p = .19 |
Inguinal fat | ARG1 | 1.27, p = .49 | 0.51, p = .02 |
Perigonadal fat | UCP1 | 1.94, p < .0001 | 0.49, p < .0001 |
Perigonadal fat | iNOS | 0.75, p < .07 | 1.15, p = .66 |
Perigonadal fat | ARG1 | 1.74, p < .0007 | 0.40, p < .0001 |
Hippocampus | BDNF | 1.68, p = .01 | 0.56, p = .009 |
Hippocampus | DCX | 1.57, p = .002 | 0.68, p = .01 |
Hippocampus | FNDC5 | 1.70, p = .04 | 0.56, p = .03 |
Hippocampus | GPLD1 | 1.15, p = .51 | 1.03, p = .99 |
Muscle | FNDC5 | 1.65, p = .0001 | 0.55, p < .0001 |
Liver | GPLD1 | 2.20, p < .0001 | 0.48, p < .0001 |
Abbreviations: BAT, brown adipose tissue; GPLD1, glycosylphosphatidylinositol specific phospholipase D1; FNDC5, fibronectin type III domain‐containing protein 5; UCP1, uncoupling protein 1.