Table 3.
Motility index of antral and duodenal pressure waves, and number, peak, and the time to peak number of isolated pyloric pressure following intragastric or intraduodenal administration of quinine in healthy men and women
| Male | Female | |||||
|---|---|---|---|---|---|---|
| IG-QHCl | ID-QHCl | P values | IG-QHCl | ID-QHCl | P values | |
| Antral pressure waves | ||||||
| MI0-120min, mmHg | 11 ± 1 | 10 ± 1 | 0.625 | 11 ± 1 | 11 ± 1 | 0.999 |
| MI0-60min, mmHg | 10 ± 1 | 8 ± 1 | 0.014 | 11 ± 1 | 11 ± 1a | 0.703 |
| MI60-120min, mmHg | 7 ± 1 | 7 ± 1 | 0.687 | 10 ± 1 | 9 ± 1b | 0.420 |
| Isolated pyloric pressure waves | ||||||
| Total number0-120min | 25 ± 10 | 36 ± 11 | 0.426 | 16 ± 6 | 56 ± 15 | 0.002 |
| Total number0-60min | 11 ± 4 | 22 ± 8 | 0.050 | 6 ± 2 | 30 ± 9 | 0.013 |
| Total number60-120min | 14 ± 6 | 14 ± 4 | 0.451 | 9 ± 4 | 26 ± 9 | 0.039 |
| Peak number | 7 ± 2 | 10 ± 2 | 0.356 | 6 ± 2 | 16 ± 3 | 0.001 |
| Time to peak number, min | 70 ± 9 | 47 ± 10 | 0.173 | 90 ± 5 | 50 ± 8 | 0.008 |
| Mean amplitude0-120min, mmHg | 18 ± 4 | 18 ± 3 | 0.345 | 21 ± 3 | 20 ± 2 | 0.333 |
| Mean amplitude0-60min, mmHg | 21 ± 3 | 21 ± 4 | 0.533 | 20 ± 3 | 22 ± 3 | 0.451 |
| Mean amplitude60-120min, mmHg | 21 ± 5 | 20 ± 3 | 0.613 | 24 ± 3 | 23 ± 3 | 0.517 |
| Duodenal pressure waves | ||||||
| MI0-120min, mmHg | 15 ± 0 | 16 ± 0 | 0.404 | 15 ± 0 | 16 ± 0 | 0.032 |
| MI0-60min, mmHg | 13 ± 0 | 14 ± 0 | 0.042 | 14 ± 0 | 15 ± 0c | 0.007 |
| MI60-120min, mmHg | 14 ± 0 | 14 ± 0 | 0.835 | 15 ± 0 | 15 ± 0 | 0.242 |
Data are means ± SEMs. n = 14 in each group.
Abbreviations: ID-QHCl, intraduodenal quinine hydrochloride; IG-QHCl, intragastric quinine hydrochloride; MI, motility index (calculated as MI (mmHg) = natural logarithm {[sum of amplitudes × number of pressure waves] + 1}).
Differences from respective values in males:
a P = 0.011,
b P = 0.045,
cP = 0.017.