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. 2022 Jul 2;8(7):e09863. doi: 10.1016/j.heliyon.2022.e09863

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Phenotypic and functional characteristics of spike re-challenged and ex vivo expanded CoV-2-STs from BNT162b2 vaccinees. Panel A Cytotoxic activity of CoV-2-STs expanded 1-month (blue dots) and 8-months (orange dots) post vaccination against autologous, unmutated spike-pulsed phytohaemagglutinin (PHA) blasts. Regression lines per group and ± SE ribbons are shown. Panel B Number of interferon-γ secreting CoV-2-STs expanded 8-months post vaccination after pulsing with the unmutated SARS-CoV-2 spike antigen, B.1.1.7 (alpha), B.1.351 (beta) and B.1.617.2 (delta) SARS-CoV-2 variants. Boxplots denote median and quartile bounds. Whiskers are placed at 1.5x interquartile range. Panel C Cytotoxic activity of CoV-2-STs expanded 8-months post vaccination against autologous, PHA blasts pulsed with the unmutated spike antigen (orange dots) or the delta variant (green dots). Regression lines per group and ± SE ribbons are shown. Panel D Immunophenotypic profile of CoV-2-STs expanded 1-month and 8-months post vaccination. CM: central memory; EM: effector memory.