Table 3.

Summary of transcription factors exclusively targeting either the wild type (WT) or the mutant sequence (MUT) of SLC15A4 upstream region

Transcription factor	Targeting	Matrix ID	Relative scorea	Start	End	Strand	Predicted sequence
MEIS2	WT	MA0774.1	0.84	116	123	+	gggacAGG
NR1D2	WT	MA1532.1	0.81	108	122	+	tgggttctgggacAG
RARA::RXRG	WT	MA1149.1	0.80	109	126	+	gggttctgggacAGGTGA
RBPJ	WT	MA1116.1	0.86	113	122	+	tctgggacAG
RORC	WT	MA1151.1	0.82	110	121	+	ggttctgggacA
SREBF1	WT	MA0595.1	0.80	118	127	–	GTCACCTgtc
STAT1	WT	MA0137.2	0.84	109	123	–	CCTgtcccagaaccc
		MA0137.3	0.88	111	121	+	gttctgggacA
TGIF2LX	WT	MA1571.1	0.81	117	128	–	GGTCACCTgtcc
			0.81	117	128	+	ggacAGGTGACC
TGIF2LY	WT	MA1572.1	0.82	117	128	–	GGTCACCTgtcc
			0.82	117	128	+	ggacAGGTGACC
GRHL2	MUT	MA1105.2	0.83	116	127	+	ggaacAGGTGAC
MYF6	MUT	MA0667.1	0.82	118	127	+	aacAGGTGAC
NFATC2	MUT	MA0152.1	0.90	115	121	–	Tgttcca
PRDM4	MUT	MA1647.1	0.81	114	124	–	ACCTgttccag
SCRT1	MUT	MA0743.1	0.83	114	128	+	ctggaacAGGTGACC
		MA0743.2	0.85	113	128	+	tctggaacAGGTGACC
SCRT2	MUT	MA0744.1	0.85	114	126	+	ctggaacAGGTGA
		MA0744.2	0.85	113	128	+	tctggaacAGGTGACC
TEF	MUT	MA0843.1	0.80	110	121	–	Tgttccagaacc
ZBTB26	MUT	MA1579.1	0.92	107	121	–	Tgttccagaacccag

Respective transcription factor binding sites (TFBS) are identified with Jaspar2020 and the default relative profile score threshold of 80%. Matrix ID, relative scores, start and end positions, strand information as well as respective binding sequences are included

^aA relative score of 1 is representing the maximum likelihood sequence for the motif