Table 2.
GO (biological process) overrepresentation analysis of ME2 module in THP-1 macrophages co-cultured with MMNK-1 cholangiocytes.
| Gene set | Description | Size | Expected | Observed | Ratio | p-value | FDR |
|---|---|---|---|---|---|---|---|
| GO:1903047 | Mitotic cell cycle process | 788 | 8.70 | 33 | 3.79 | 3.2E−11 | 2.9E−07 |
| GO:0007049 | Cell cycle | 1739 | 19.20 | 44 | 2.29 | 1.0E−07 | 1.3E−04 |
| GO:0048285 | Organelle fission | 459 | 5.07 | 19 | 3.75 | 8.1E−07 | 6.1E−04 |
| GO:0051338 | Regulation of transferase activity | 940 | 10.38 | 27 | 2.60 | 4.7E−06 | 2.7E−03 |
| GO:0010324 | Membrane invagination | 60 | 0.66 | 6 | 9.06 | 5.1E−05 | 1.1E−02 |
| GO:0051276 | Chromosome organization | 1143 | 12.62 | 27 | 2.14 | 1.4E−04 | 2.3E−02 |
| GO:0009435 | NAD biosynthetic process | 53 | 0.59 | 5 | 8.54 | 2.9E−04 | 4.0E−02 |
The table shows GO (biological process) overrepresentation analysis of ME2 module from the transcriptomic profiles of THP-1 macrophages co-cultured with MMNK-1 cholangiocytes when exposed to 1,2-DCP at 0, 0.1 or 0.4 mM for 24 h. The analysis was performed by WebGestalt with False Discovery Rate (FDR) cut-off value of 0.05.