Table 4.
Association of the gene common variants with SLE.
| Gene | Variant | ID | ACMG | Number of alleles | MAF | ||
|---|---|---|---|---|---|---|---|
| Patients N = 182 |
Controls N = 182 |
Patients | Controls | ||||
| TNFSF13B | c.340-45C>G | rs56124946 | B | 8 | 3 | 0.04 | 0.02 |
| TNFSF13 | p.Gly67Arg1 | rs11552708 | B | 18 | 6 | 0.10 | 0.03 |
| p.Asn96Ser2 | rs3803800 | B | 143 | 142 | 0.21 | 0.22 | |
| c.505-20_505-18delACA | rs58840546 | B | 12 | 11 | 0.07 | 0.06 | |
| TNFRSF13B | c.*173G>A | rs56153623 | B | 71 | 66 | 0.39 | 0.36 |
| p.Ser277Ser | rs11078355 | B | 79 | 77 | 0.43 | 0.42 | |
| p.Pro251Leu | rs34562254 | B | 21 | 15 | 0.12 | 0.08 | |
| c.632-60T>C | rs11652811 | B | 60 | 60 | 0.33 | 0.33 | |
| c.445+144A>G | rs4517836 | B | 57 | 56 | 0.31 | 0.31 | |
| c.445+25A>C | rs2274892 | VUS | 84 | 76 | 0.46 | 0.42 | |
| p.Thr27Thr | rs8072293 | LB | 119 | 118 | 0.65 | 0.65 | |
| TNFRSF13C | c.368-33T>C | rs5996087 | VUS | 16 | 14 | 0.09 | 0.08 |
| c.367+89G>C | rs73165134 | VUS | 16 | 11 | 0.09 | 0.06 | |
| c.136+140G>A | rs150150552 | B | 0 | 3 | 0.00 | 0.02 | |
| TNFRSF17 | p.Thr159Thr | rs2017662 | B | 11 | 13 | 0.06 | 0.07 |
| p.Thr175Thr | rs2071336 | B | 6 | 9 | 0.03 | 0.05 | |
ACMG American College of Medical Genetics and Genomics. 1All p-values > 0.05 except TNFSF13 p.Gly67Arg p value = 0.014 FDRadj.pval > 0.05. 2MAF (Minor Allele Frequency) correspond to the reference that is the minor allele in EUR.