Table 2.
Table comparing demographics of double positivity SSc specific autoantibody group and cohort of patients with individual autoantibody.
| Double antibody group | Comparator group | Demographics | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Age (years) | Sex (male) | Overlap | SSc diffuse | ||||||
| N | P | N | p | n | p | n | p | ||
| U1 RNP and ATA (n = 21) | 51.38 ± 11.56 | 3 (14%) | 9 (43%) | 16 (76%) | |||||
| U1RNP | 58.64 ± 13.10 | 0.05 | 15 (20%) | 0.755 | 40 (53%) | 0.464 | 16 (21%) | 0.001 | |
| ATA | 62.03 ± 15.04 | 0.002 | 50 (19%) | 0.775 | 41 (15%) | 0.004 | 140 (52%) | 0.041 | |
| U1RNP and ACA (n = 8) | 57.88 ± 10.87 | 1 (12%) | 3 (37%) | 2 (25%) | |||||
| U1RNP | 58.64 ± 13.10 | 0.873 | 15 (20%) | 1 | 40 (53%) | 0.473 | 16 (21%) | 0.678 | |
| ACA | 68.75 ± 12.61 | 0.015 | 34 (9%) | 0.532 | 59 (15%) | 0.119 | 10 (3%) | 0.022 | |
| U1RNP and ARA (n = 4) | 58.0 ± 8.76 | 1 (25%) | 0 | 3 (75%) | |||||
| U1RNP | 58.64 ± 13.10 | 0.923 | 15 (20%) | 1 | 40 (53%) | 0.05 | 16 (21%) | 0.04 | |
| ARA | 64.46 ± 11.92 | 0.161 | 29 (20%) | 1 | 12 (8%) | 1 | 126 (88%) | 0.41 | |
| U1 RNP and PmScl (n = 3) | 50.67 ± 24.44 | 1 (33%) | 3 (100%) | 0 | |||||
| U1RNP | 58.64 ± 13.10 | 0.319 | 15 (20%) | 0.498 | 40 (53%) | 0.248 | 16 (21%) | 1 | |
| PmScl | 62.20 ± 14.19 | 0.191 | 11 (20%) | 0.515 | 27 (50%) | 0.239 | 20 (37%) | 0.545 | |
| ATA and ACA (n = 4) | 62.25 ± 10.21 | 0 | 1 (25%) | 1 (25%) | |||||
| ATA | 62.03 ± 15.04 | 0.67 | 50 (19%) | 1 | 41 (15%) | 0.496 | 140 (52%) | 1 | |
| ACA | 68.75 ± 12.61 | 0.581 | 34 (9%) | 1 | 59 (15%) | 0.493 | 10 (3%) | 0.11 | |
| ACA and PmScl (n = 4) | 69.25 ± 20.22 | 0 | 2 (50%) | 1 (25%) | |||||
| ACA | 68.75 ± 12.61 | 1 | 34 (9%) | 1 | 59 (15%) | 0.119 | 10 (3%) | 0.11 | |
| PmScl | 62.20 ± 14.19 | 0.355 | 11 (20%) | 1 | 27 (50%) | 1 | 20 (37%) | 1 | |
| ACA and U3RNP (n = 2) | 51.50 ± 2.12 | 0 | 1 (50%) | 0 | |||||
| ACA | 68.75 ± 12.61 | 0.045 | 34 (9%) | 1 | 59 (15%) | 0.288 | 10 (3%) | 1 | |
| U3RNP | 59.70 ± 14.89 | 0.466 | 19 (38%) | 0.527 | 11 (22%) | 0.419 | 29 (58%) | 0.191 | |
| PmScl and Ku (n = 2) | 49.0 ± 1.41 | 0 | 2 (100%) | 0 | |||||
| PmScl | 62.20 ± 14.19 | 0.198 | 11 (20%) | 1 | 27 (50%) | 0.492 | 20 (37%) | 0.532 | |
| Ku | 70.2 ± 24.49 | 0.3 | 1 (20%) | 1 | 2 (40%) | 0.429 | 1 (20%) | 1 | |
| U1RNP and U3 RNP (n = 6) | 55.50 ± 8.26 | 0 | 2 (33%) | 3 (50%) | |||||
| U1RNP | 58.64 ± 13.10 | 0.566 | 15 (20%) | 0.586 | 40 (53%) | 0.421 | 16 (21%) | 0.134 | |
| U3RNP | 59.70 ± 14.89 | 0.503 | 19 (38%) | 0.086 | 11 (22%) | 0.619 | 29 (58%) | 1 | |
| ATA and Ku (n = 3) | 56.0 ± 2.64 | 0 | 1 (33%) | 2 (66%) | |||||
| ATA | 62.03 ± 15.04 | 0.489 | 50 (19%) | 1 | 41 (15%) | 0.403 | 140 (52%) | 1 | |
| Ku | 70.2 ± 24.49 | 0.489 | 1 (20%) | 1 | 2 (40%) | 1 | 1 (20%) | 0.464 | |
Significant p values (< 0.05) are highlighted in bold.