Table 2.
SNP-by-AD status interaction meta-analysis for ε4-associated group-specific SNPs in the pooled samples of AD and NAD groups.
| SNPs | SNP-by-AD Status Interaction Effect | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rep/Meta | CHR | Locus | Gene | SNP | POS | EA | EAF | N | BETA | SE | P-value | Effects |
| NAD-Meta | 1p31.2 | 1 | LRRC7 | rs1414663 | 69168451 | G | 0.102 | 11576 | −0.423 | 0.108 | 8.60E-05 | −−?−− |
| AD-Meta | 8q24.22 | 2 | KCNQ3 | rs9297847 | 132351982 | T | 0.318 | 15047 | −0.292 | 0.066 | 8.90E-06 | −−−−− |
| AD-Meta | 8q24.22 | 2 | KCNQ3 | rs4458854 | 132360860 | A | 0.338 | 15048 | −0.277 | 0.065 | 2.00E-05 | −−−−− |
| AD-Meta | 8q24.22 | 2 | KCNQ3 | rs7820317 | 132362575 | A | 0.339 | 15044 | −0.265 | 0.065 | 4.58E-05 | −−−−− |
| AD-Meta | 8q24.22 | 2 | KCNQ3 | rs2673604 | 132399360 | C | 0.299 | 15044 | −0.281 | 0.067 | 2.98E-05 | −−−−− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | NECTIN2 | rs283815 | 44887076 | G | 0.307 | 11576 | −0.274 | 0.052 | 1.54E-07 | −−?−− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | TOMM40 | rs71352238 | 44891079 | C | 0.245 | 11573 | −0.475 | 0.061 | 4.90E-15 | −−?−− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | TOMM40 | rs157580 | 44892009 | G | 0.314 | 10506 | −0.316 | 0.071 | 9.68E-06 | ?−?−− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | TOMM40 | rs2075650 | 44892362 | G | 0.243 | 11570 | −0.553 | 0.061 | 1.17E-19 | −−?−− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | TOMM40 | rs34095326 | 44892587 | A | 0.184 | 11576 | −0.542 | 0.077 | 1.81E-12 | −−?−− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | TOMM40 | rs157582 | 44892962 | T | 0.307 | 11574 | −0.282 | 0.052 | 6.53E-08 | −−?−− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | TOMM40 | rs76366838 | 44896639 | A | 0.048 | 8875 | −0.937 | 0.178 | 1.40E-07 | −−??− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | TOMM40 | rs8106922 | 44898409 | G | 0.369 | 11559 | −0.395 | 0.062 | 2.38E-10 | −−?−− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | TOMM40 | rs115881343 | 44899959 | T | 0.050 | 8874 | −0.910 | 0.172 | 1.29E-07 | −−??− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | TOMM40 | rs1160985 | 44900155 | T | 0.391 | 11576 | −0.435 | 0.061 | 8.42E-13 | −−?−− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | TOMM40 | rs7259620 | 44904531 | A | 0.388 | 11576 | −0.413 | 0.061 | 1.18E-11 | −−?−− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | APOE | rs405509 | 44905579 | G | 0.437 | 11572 | −0.286 | 0.063 | 5.06E-06 | −−?−− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | APOE | rs769449 | 44906745 | A | 0.225 | 11573 | −1.065 | 0.053 | 3.18E-91 | −−?−− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | APOE | rs769450 | 44907187 | A | 0.372 | 11574 | −0.422 | 0.062 | 1.18E-11 | −−?−− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | APOE | rs75627662 | 44910319 | T | 0.228 | 11576 | −0.994 | 0.053 | 1.40E-79 | −−?−− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | APOE | rs72654473 | 44911142 | A | 0.051 | 11572 | −0.770 | 0.147 | 1.84E-07 | −−?−− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | APOE | rs439401 | 44911194 | T | 0.342 | 11558 | −0.270 | 0.065 | 3.68E-05 | +−?−− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | APOC1 | rs445925 | 44912383 | A | 0.054 | 11575 | −0.741 | 0.144 | 2.71E-07 | −−?−− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | APOC1 | rs483082 | 44912921 | T | 0.286 | 11574 | −0.747 | 0.044 | 3.31E-65 | −−?−− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | APOC1 | rs584007 | 44913221 | A | 0.341 | 11573 | −0.274 | 0.065 | 2.81E-05 | +−?−− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | APOC1 | rs56131196 | 44919589 | A | 0.287 | 12347 | −0.447 | 0.046 | 1.63E-22 | −−−?− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | APOC1 | rs4420638 | 44919689 | G | 0.287 | 12332 | −0.451 | 0.046 | 8.56E-23 | −−−?− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | APOC1 | rs78959900 | 44920379 | A | 0.298 | 5508 | −0.463 | 0.090 | 2.94E-07 | −???− |
| AD-Rep/NAD-Rep | 19q13.32 | 3 | APOC1P1 | rs4803770 | 44924096 | G | 0.325 | 5508 | −0.516 | 0.087 | 3.36E-09 | −???− |
| AD-Meta/NAD-Meta | 19q13.32 | 3 | APOC1P1 | rs71352239 | 44926286 | T | 0.280 | 4450 | −0.434 | 0.107 | 5.33E-05 | ????− |
| AD-Rep | 19q13.32 | 3 | EXOC3L2 | rs11083767 | 45212422 | C | 0.338 | 5508 | −0.418 | 0.097 | 1.61E-05 | −???− |
Please see the description provided below Table 1.