Table 3.
Bonferroni-adjusted significant results from the survival-type analysis of the main and interaction effects of the rs7412 or rs429358 (i.e., ε2- or ε4-encoding SNPs) and the ε2/ε4-associated group-specific SNPs on the AD risks in the pooled samples of AD and NAD groups.
| SNPs | SNP Main Effect | rs7412 or rs429358 Main Effect | Interaction Effect | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CHR | Gene | SNP | POS | EA | EAF | N | BETA | SE | P-value | BETA | SE | P-value | BETA | SE | P-value |
| ε2-associated group-specific SNPs | |||||||||||||||
| 1p13.3 | VAV3 | rs77841908 | 107713714 | T | 0.012 | 5430 | −0.062 | 0.225 | 7.83E-01 | −0.655 | 0.091 | 7.73E-13 | 1.418 | 0.363 | 9.32E-05 |
| 8q24.3 | MROH5 | rs77186917 | 141434800 | C | 0.047 | 6513 | −0.038 | 0.086 | 6.63E-01 | −0.734 | 0.090 | 5.35E-16 | 0.724 | 0.200 | 3.04E-04 |
| 11q22.3 | DDX10 | rs2884183 | 109127412 | T | 0.213 | 6849 | −0.136 | 0.045 | 2.54E-03 | −0.750 | 0.099 | 2.97E-14 | 0.451 | 0.112 | 6.00E-05 |
| 16q24.1 | IRF8 | rs16882 | 85901967 | C | 0.180 | 6853 | −0.110 | 0.048 | 2.09E-02 | −0.743 | 0.095 | 4.84E-15 | 0.441 | 0.115 | 1.32E-04 |
| 16q24.1 | IRF8 | rs305082 | 85903372 | C | 0.183 | 6846 | −0.111 | 0.047 | 1.93E-02 | −0.756 | 0.095 | 2.23E-15 | 0.457 | 0.116 | 8.75E-05 |
| 17q25.1 | SDK2 | rs9895288 | 73623974 | A | 0.078 | 6854 | −0.052 | 0.070 | 4.60E-01 | −0.638 | 0.084 | 3.99E-14 | 0.598 | 0.172 | 5.07E-04 |
| 17q25.1 | SDK2 | rs75122991 | 73639797 | G | 0.069 | 6853 | −0.057 | 0.074 | 4.45E-01 | −0.638 | 0.083 | 2.06E-14 | 0.662 | 0.178 | 1.99E-04 |
| 17q25.1 | SDK2 | rs28527783 | 73640957 | T | 0.069 | 6854 | −0.061 | 0.074 | 4.10E-01 | −0.639 | 0.083 | 1.96E-14 | 0.664 | 0.178 | 1.91E-04 |
| 17q25.1 | SDK2 | rs76380229 | 73643396 | T | 0.069 | 6852 | −0.066 | 0.074 | 3.78E-01 | −0.640 | 0.083 | 1.87E-14 | 0.667 | 0.178 | 1.76E-04 |
| 20q13.2 | ZFP64 | rs6021874 | 52342233 | C | 0.085 | 6855 | −0.152 | 0.067 | 2.34E-02 | −0.665 | 0.086 | 8.45E-15 | 0.611 | 0.155 | 8.23E-05 |
| 20q13.2 | ZFP64 | rs6021877 | 52345128 | T | 0.086 | 6854 | −0.147 | 0.067 | 2.79E-02 | −0.662 | 0.086 | 1.13E-14 | 0.595 | 0.154 | 1.20E-04 |
| 20q13.2 | ZFP64 | rs2426435 | 52357570 | A | 0.083 | 6854 | −0.162 | 0.068 | 1.81E-02 | −0.660 | 0.085 | 1.01E-14 | 0.609 | 0.156 | 9.86E-05 |
| ε4-associated group-specific SNPs | |||||||||||||||
| 19q13.32 | APOE | rs769449 | 44906745 | A | 0.217 | 9932 | 0.352 | 0.068 | 2.19E-07 | 0.698 | 0.045 | 1.17E-54 | −0.120 | 0.037 | 1.24E-03 |
| 19q13.32 | APOE | rs72654473 | 44911142 | A | 0.051 | 9932 | 0.337 | 0.104 | 1.23E-03 | 0.875 | 0.026 | 1.18E-241 | −0.266 | 0.074 | 2.95E-04 |
| 19q13.32 | APOC1 | rs445925 | 44912383 | A | 0.053 | 9934 | 0.322 | 0.103 | 1.83E-03 | 0.877 | 0.026 | 3.84E-242 | −0.257 | 0.073 | 4.70E-04 |
| 19q13.32 | APOC1 | rs483082 | 44912921 | T | 0.277 | 9933 | 0.483 | 0.076 | 2.27E-10 | 0.593 | 0.077 | 1.17E-14 | −0.110 | 0.033 | 9.05E-04 |
Please see the description provided below Table 1. The Bonferroni-adjusted significance thresholds were 1.43E-03 (i.e., 0.05/35) and 1.61E-03 (i.e., 0.05/31) in the ε2 and ε4 analyses, respectively.