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. 2022 Jan 3;18(10):1889–1897. doi: 10.1002/alz.12514

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© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Potentially qualifying families (A) were recruited by the National Institute on Aging Late‐Onset Alzheimer's Disease Family Based Study (NIA‐LOAD FBS) investigators (B). Blood was sent to National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) (C). NCRAD supplied biological samples to the Alzheimer's Disease Sequencing Projects (ADSP) (D) and to other qualified individual investigators (D) along with phenotype data from the Columbia University Coordinating Center. Any new data generated by investigators was required to be shared by sending it to National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS; E) where other investigators could request clinical and genetic results from these studies (F)