FIGURE 2.

Results of genome‐wide array in the National Institute on Aging Late‐Onset Alzheimer's Disease Family Based Study (NIA‐LOAD FBS). The apolipoprotein E (APOE) locus reached genome‐wide significance in association with Alzheimer's disease (AD). However, a number of other loci, labeled on the Manhattan plot below, were nominally significant. Many of these loci supported several large meta‐analyses that included other cohorts ²⁷ , ²⁸ , ²⁹