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. Author manuscript; available in PMC: 2023 Jul 1.
Published in final edited form as: Prog Retin Eye Res. 2022 Jan 4;89:101039. doi: 10.1016/j.preteyeres.2021.101039

Figure 6. The downregulation of Sirt1/miR-182 in the trigeminal ganglion of diabetic type 2 db/db mice.

Figure 6.

In diabetic trigeminal ganglion, the normal expression of sirt1 was impaired, resulting in inhibiting expression of its downstream miRNA miR-182, causing excess expression of the target gene NOX4 of miR-182, thereby induing an overexpression of ROS. These changes eventually lead to the delay of corneal epithelial wound healing and corneal nerve regeneration. This diagram has not been published and was made by B Zhang.