Table 2.

Summary of miRNAs in the diabetic cornea and TG

Name	Change (DM vs. NL)	Functions	References
miR-146a	↑ in cornea	Delay epithelial wound healing. Inhibit epithelial cells migration. Limbal epithelial cells (LEC) maintenance. Reduce p-p38 and p-EGFR expression.	(Funari et al., 2013; Winkler et al., 2014)
miR-424	↑ in cornea	Delay epithelial wound healing. Reduce p-p38 and p-EGFR expression	(Funari et al., 2013)
miR-10b	↑ in corneal limbus	Increase corneal epithelial cell proliferation. LESC maintenance and/or their early differentiation.	(Kulkarni et al., 2017)
miR-182	↓ in TG	Promote nerve regeneration. Recovery of corneal sensation. Decrease its target gene NOX4.	(Wang et al., 2016)
miR-204–5p	↑ in corneal epithelia	Upregulate Sirt1. Delay epithelial cell cycle. Inhibit corneal epithelial wound healing.	(Gao et al., 2015a)
miR-409–3p	/	Upregulate c-Met. Accelerate epithelial wound healing	(Kramerov et al., 2021)
miR-181a	↑ in TG	Decrease nerve regeneration. Alleviate corneal epithelium healing. Decrease ATG5-mediated autophagic activation. Reduce BCL-2-mediated inhibition of apoptosis.	(Hu et al., 2020)
miR-214	↓ in corneal endothelium	Attenuate high glucose induced pyroptosis.	(Zhang et al., 2020c)
miR-34c	↑ in TG	Affect the growth of trigeminal sensory neurons. Affect the repair of diabetic corneal nerve endings. Inhibit autophagy by acting directly on Atg4B.	(Hu et al., 2019)