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. Author manuscript; available in PMC: 2022 Oct 24.
Published in final edited form as: Nat Biomed Eng. 2022 Jan 3;6(10):1167–1179. doi: 10.1038/s41551-021-00810-0

Fig. 1 |. An overview of the vision for the multifunctional performance of the Janus Tough Adhesives (JTAs) for tendon.

Fig. 1 |

JTA hydrogels were engineered that comprise a tough hydrogel dissipative matrix and adhesive chitosan surface. The tough hydrogel was synthesized by combining alginate ionically crosslinked with calcium and covalently crosslinked polyacrylamide (PAAM). Beyond tissue adhesion, the material can promote gliding of surrounding tissues and serve as a drug delivery system for local release of agents such as triamcinolone acetonide as exemplified in the present study.