Fig. 5.

Example of loop-binding mode—synthetic zinc finger, Gq1 targeting a telomeric G4Q. Computationally derived model (PDB from Ladame, et al. 2006), showing overall arrangement (center) and key residues from A the first “finger,” whereby His125, Arg124, and Arg127 interact with the two outward-directed T12 and A13 nucleotides; B the second “finger,” where His153 and Thr156 bind with phosphate backbone of G10, while Arg142 wraps under to bind the other protruding nucleotide, T11; and C the third “finger,” where the Ser175, Arg178, and Thr182 create extensive H-bonds with the phosphate backbone of the loop