Table 1.
Liposome characterization
Sample | Size (nm) | PDI | Drug-Loading (%) | Encapsulation Efficiency (%) |
---|---|---|---|---|
Lipo | 86.0 ± 0.6 | 0.133 ± 0.007 | - | - |
2-PAM@Lipo | 89.5 ± 0.6a | 0.062 ±0.023b | 4.7 ± 0.4% | 33.9 ± 3.2% |
2-PAM@46.1-Lipo | 88.2 ± 0.1 | 0.084 ± 0.011 | 4.4 ± 0.4% | 30.6 ± 3.3% |
2-PAM@Ctrl-Lipo | 88.1 ± 1.9 | 0.096 ± 0.042 | 4.6 ± 0.2% | 31.7 ± 2.1% |
2-PAM@46.1-Lipo (30 days) | 93.6 ± 3.2 nmc | 0.194 ± 0.069 | - | - |
2-PAM@Ctrl-Lipo (30 days) | 91.6 ± 0.3 nmd | 0.073 ± 0.017 | - | - |
Size for Lipo versus 2-PAM@Lipo, p<0.05
PDI for Lipo versus 2-PAM@Lipo, p<0.05
Size for 2-PAM@46.1-Lipo (30days) versus 2-PAM@46.1-Lipo, no change, p>0.05
Size for 2-PAM@Ctrl-Lipo (30days) versus 2-PAM@Ctrl-Lipo, no change, p>0.05
All other comparisons: p > 0.05, no significant differences among groups from 2-PAM@Lipo, 2-PAM@46.1-Lipo and 2-PAM@Ctrl-Lipo for hydrodynamic size, PDI, DL and EE by one-way ANOVA followed by Tukey’s HSD test.