Table 3.
Multivariable Analyses for the Combined Study Populations of NSABP B-40 and B-41 Evaluating the Association of Regional Nodal Irradiation with Local-regional Recurrence, Distant Recurrence, Disease-free Survival, and Overall Survival
| LRR | DR | DFS | OS | |||||
|---|---|---|---|---|---|---|---|---|
| Variables | HR | P value | HR | P value | HR | P value | HR | P value |
| RNI | 0·79 | 0·299 | 0·97 | 0·808 | 0·92 | 0·496 | 0·86 | 0·306 |
| Age | 0·98 | 0·069 | 0·99 | 0·045 | 0·99 | 0·047 | 0·99 | 0·274 |
| Tumor subtype | <0·001 | <0·001 | <0·001 | <0·001 | ||||
| HR+/HER2− | 1·94 | 0·023 | 1·12 | 0·523 | 1·29 | 0·101 | 0·91 | 0·691 |
| TN vs HR+/HER2− | 3·30 | <0·001 | 1·88 | <0·001 | 2·01 | <0·001 | 2·24 | <0·001 |
| Breast pCR | 0·48 | 0·008 | 0·46 | <0·001 | 0·56 | <0·001 | 0·45 | <0·001 |
| Axillary pCR | 0·39 | <0·001 | 0·30 | <0·001 | 0·32 | <0·001 | 0·23 | <0·001 |
| Clinical node positivity | NS | NS | 1·41 | 0·014 | NS | NS | NS | NS |
| Grade | NS | 0·011 | 0·004 | 0·001 | ||||
| Grade 2 vs 1 | NS | NS | 1·99 | 0·080 | 2·22 | 0·022 | 1·98 | 0·144 |
| Grade 3 vs 1 | NS | NS | 2·66 | 0·014 | 2·72 | 0·004 | 3·32 | 0·011 |
| Clinical tumor size | NS | NS | NS | NS | 1·11 | <0·001 | 1·11 | <0·001 |
Abbreviations: LRR, local-regional recurrence; DR, distant recurrence; DFS, disease-free survival; OS, overall survival; pCR, pathological complete response; RNI, regional nodal irradiation; TN, triple negative; NS, not significant