Table 2.

Top 20 CpGs associated with the four methylation subtypes.

CpG	CHR	Position	Gene group	Gene	Subtype1 mean	Subtype2 mean	Subtype3 mean	Subtype4 mean	p-value*
cg26415547	12	66583048	1stExon|5’UTR	IRAK3	0.12	0.08	0.34	0.34	2.58×10−45
cg13009111	11	71350975		KRTAP5–11|FAM86C	0.17	0.1	0.3	0.35	6.75×10−41
cg21884421	15	65648103	Body	IGDCC3	0.13	0.16	0.48	0.32	1.59×10−38
cg07462540	7	8473279	TSS1500	NXPH1	0.12	0.11	0.24	0.35	2.07×10−36
cg20750832	5	170742345		TLX3 |NPM1	0.21	0.22	0.49	0.49	2.88×10−36
cg16332256	4	9534388		DEFB131/MIR548I2	0.14	0.11	0.27	0.42	4.83×10−36
cg02145932	20	13200969	TSS1500	ISM1	0.12	0.05	0.3	0.36	1.10×10−35
cg15720669	3	138666040	TSS200	FOXL2|C3orf72	0.09	0.13	0.37	0.3	1.56×10−35
cg12072560	18	12254173	TSS1500|TSS200	CIDEA	0.13	0.11	0.38	0.32	9.4×10−35
cg17802942	3	138666050	TSS200	FOXL2|C3orf72	0.08	0.13	0.36	0.28	1.61×10−34
cg00114029	1	35351407	Body	DLGAP3	0.14	0.13	0.31	0.37	1.19×10−33
cg18932798	10	105037503	1stExon	INA	0.12	0.06	0.28	0.37	1.61×10−32
cg15980539	6	152128865	5’UTR|1stExon	ESR1	0.12	0.11	0.29	0.32	1.64×10−32
cg11120927	2	239072674		KLHL30/ILKAP	0.1	0.19	0.42	0.33	1.82×10−32
cg15041550	6	39016590	1stExon|5’UTR	GLP1R	0.16	0.16	0.41	0.33	2.95×10−32
cg12664209	20	13200954	TSS1500	ISM1	0.21	0.07	0.42	0.49	7.97×10−32
cg11850773	18	904963	5’UTR|TSS1500|1stExon	ADCYAP1	0.13	0.17	0.24	0.32	2.23×10−31
cg00851770	18	12254175	TSS1500|TSS200	CIDEA	0.09	0.08	0.29	0.24	2.30×10−31
cg27109129	4	74864165	Body	CXCL5	0.23	0.28	0.63	0.5	3.20×10−31
cg03382304	21	27012176	1stExon	JAM2	0.13	0.07	0.21	0.29	3.22×10−31

^*p-value is computed using ANOVA for association with 4 Subtypes.