Table 2.
Summary of neoplastic diagnoses in nonhuman primate radiation late effects cohort
| Diagnosis | Number observed (irradiated) | Number observed (controls) | Anatomic sites |
|---|---|---|---|
|
| |||
| Sarcoma | |||
| MNST | 6 | 0 | Skin/subcutis, liver, kidney |
| Malignant glomus tumor | 5 | 0 | Skin/subcutis, kidney, seminal vesicles, liver |
| Endothelial malignancies | 5 | 0 | Skin/subcutis, spleen, liver, lung |
| Fibrosarcoma | 1 | 0 | Skin/subcutis |
| Leiomyosarcoma | 1 | 0 | Small intestine |
| Myxosarcoma | 1 | 0 | Skin/subcutis |
| Osteosarcoma | 1 | 0 | Skull |
| GIST | 1 | 0 | Colon |
| Carcinoma | |||
| HCC | 3 | 1 | Liver |
| RCC | 3 | 0 | Kidney |
| Biliary carcinoma | 1 | 0 | Liver |
| Mammary carcinoma | 1 | 0 | Mammary gland |
| BCC | 1 | 0 | Skin/subcutis |
| SCC | 1 | 0 | Skin/subcutis |
| Trophoblastic tumor | 1 | 0 | Uterus |
| Benign mesenchymal | |||
| Leiomyoma | 4 | 0 | Uterus, liver |
| Neurofibroma | 3 | 0 | Skin/subcutis |
| Lipoma | 3 | 0 | Skin/subcutis |
| Fibroma | 2 | 0 | Skin/subcutis |
| Chondrolipoma | 1 | 0 | Skin/subcutis |
| Hemangioma | 1 | 0 | Skin/subcutis |
| Benign epithelial/adenoma | |||
| Renal adenoma | 3 | 0 | Kidney |
| Benign follicular tumor | 2 | 0 | Skin/subcutis |
| Hepatocellular adenoma | 1 | 0 | Liver |
| Biliary adenoma | 1 | 0 | Liver |
| Other | |||
| Glioblastoma | 1 | 0 | Brain |
| Melanocytoma | 1 | 0 | Skin/subcutis |
| Meningioma | 1 | 0 | Brain |
| Lymphoma | 2 | 0 | Brain, mediastinum |
| AML | 1 | 0 | Bone marrow |
| Leydig cell tumor | 1 | 0 | Testis |
| Chemoreceptor tumor | 1 | 0 | Heart base |
Abbreviations: AML = acute myeloid leukemia; BCC = basal cell carcinoma; GIST = gastrointestinal stromal tumor; HCC = hepatocellular carcinoma; MNST = malignant nerve sheath tumor; NHP = nonhuman primate; RCC = renal cell carcinoma; RLEC = radiation late effects cohort; SCC = squamous cell carcinoma.