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. 2022 May 6;28(13):2854–2864. doi: 10.1158/1078-0432.CCR-21-3695

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©2022 The Authors; Published by the American Association for Cancer Research

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Figure 5. Translocation breakpoints. A, IGH@ locus breakpoints broken down by partner chromosome. V regions not shown for clarity. Captured regions extend to each V region. B, MYC region breakpoints broken down by Ig, non-Ig common (FOXO3, TXNDC5, FAM46C), and other partners. A kernel density plot shows the two main translocation hotspots centromeric of MYC and telomeric of PVT1. — Translocation breakpoints. A,IGH@ locus breakpoints broken down by partner chromosome. V regions not shown for clarity. Captured regions extend to each V region. B,MYC region breakpoints broken down by Ig, non-Ig common (FOXO3, TXNDC5, FAM46C), and other partners. A kernel density plot shows the two main translocation hotspots centromeric of MYC and telomeric of PVT1.