Table 2:
Rats’ gender, weight, and PLA8 NP bioavailability (BA) post 5h in vivo ILs as calculated by calibration methods #1 (subtraction) and #2 (division). F/M - Female/Male rat.
| Rat | Weight (g) | PLA8 Dosage (mg) | Blood volume (mL) | Dry serum mass (mg)** | Method #1 – Subtraction average | Method #2 – Division average | ||
|---|---|---|---|---|---|---|---|---|
| % in serum | BA (%) | % in serum | BA (%) | |||||
| #1-F | 367 | 91 | 20.9 | 878±152 | 3.7±1.6 | 36±16 | 5.3±3.4 | 51±33 |
| #2-F | 270 | 77 | 15.4 | 646±112 | NA | NA | NA | NA |
| #3-M | 450 | 67 | 25.7 | 1077±186 | 2.6±0.9 | 42±14 | 2.6±1.5 | 43±25 |
| #4-M | 510 | 75 | 29.1 | 1221±211 | 2.1±0.9 | 35±14 | 2.1±1.5 | 34±24 |
| #5-M | 766 | 85 | 26.0* | 1094±189 | 6.6±1.2 | 85±16 | 3.5±0.5 | 45±7 |
| #6-M | 580 | 167 | 33.1 | 1388±240 | 2.6±1.3 | 22±11 | 2.1±1.4 | 18±12 |
| #7-M | 433 | 147 | 24.7 | 1036±179 | 5.0±1.6 | 35±11 | 3.0±1.7 | 21±12 |
| #8-M | 541 | 145 | 30.8 | 1294±224 | 2.0±0.6 | 17±6 | 1.8±0.9 | 16±8 |