. Author manuscript; available in PMC: 2023 Jul 1.

Published in final edited form as: Immunol Cell Biol. 2022 May 25;100(6):409–423. doi: 10.1111/imcb.12555

Table 1.

cGAS-STING-dependent cell death. Summary of cGAS-STING-dependent cell death described in the main text.

Cell Death	Cell Types	Stimulation / Model	References
Apoptosis	T cells	Small molecule STING agonist	38
	T cells	STING gain-of-function mutant (N154S in human, N153AS in mice)	39, 40
	HNSCC cells	DNA-damaging agent, radiation	41
Necroptosis	L929 fibroblasts	Sendai virus (SeV), murine gammaherpesvirus-68 (MHV68)	42
	HT29 colon cancer cells	SMAC mimetic (LBW-242) + pan-caspase inhibitor (z-VAD-fmk)	43
	Mice (in vivo)	Ischemia reperfusion (I/R) injury	44
Pyroptosis	BMDMs	Chlamydia trachomatis, Francisella novicida	45, 46
Pyroptosis	BLaER human monocytes	Horse testis (HT)-DNA lipofection	47

HNSCC, Head and neck squamous cell carcinomas; BMDM, bone marrow-derived macrophage; BLaER, tamoxifen-inducible derivative of the RCH-ACV B-cell leukemia cell line.