Table 1.
Clinicopathological characteristics and neoadjuvant therapy received.
| Characteristic | Metaplastic n=39 |
Non-metaplastic n=172 |
Total n=211 |
p value | |
|---|---|---|---|---|---|
| Median age at diagnosis – years (interquartile range) | 56.2 (45.6-63.5) | 54.9 (45.1-61.1) | 55.1 (45.4-61.6) | 0.47 | |
| Race - n (%) | White | 27 (69.2) | 100 (58.1) | 127 (60.2) | 0.64 |
| Black | 4 (10.3) | 34 (19.8) | 38 (18.0) | ||
| Hispanic | 5 (12.8) | 24 (14.0) | 29 (13.7) | ||
| Asian | 3 (7.7) | 12 (7.0) | 15 (7.1) | ||
| Other | 0 | 2 (1.2) | 2 (1.0) | ||
| Median tumor size – cm (interquartile range) | 3.4 (2.2-5.2) | 2.7 (2.1-3.9) | 2.8 (2.1-4.0) | 0.09 | |
| T category - n (%) | T1 | 7 (18.0) | 27 (15.7) | 34 (16.1) | 0.37 |
| T2 | 22 (56.4) | 118 (68.6) | 140 (66.4) | ||
| T3 | 7 (18.0) | 20 (11.6) | 27 (12.8) | ||
| T4 | 3 (7.7) | 7 (4.1) | 10 (4.7) | ||
| Nodal Status - n (%) | Negative | 33 (84.6) | 90 (52.3) | 123 (58.3) | <0.001 |
| Positive | 6 (15.4) | 82 (47.7) | 88 (41.7) | ||
| TNM Stage - n (%) | I | 5 (12.8) | 15 (8.7) | 20 (9.5) | 0.35 |
| II | 28 (71.8) | 114 (66.3) | 142 (67.3) | ||
| III | 6 (15.4) | 43 (25.0) | 49 (23.2) | ||
| Histologic grade - n (%) | 1 | 1 (2.6) | 0 | 1 (0.5) | 0.04 |
| 2 | 9 (23.1) | 22 (12.8) | 31 (14.7) | ||
| 3 | 29 (74.4) | 150 (87.2) | 179 (84.8) | ||
| Ki-67 - n (%) | Low | 3 (7.7) | 8 (4.7) | 11 (5.2) | 0.03 |
| Moderate | 12 (30.8) | 28 (16.3) | 40 (19.0) | ||
| High | 21 (53.9) | 133 (77.3) | 154 (73.0) | ||
| Missing | 3 (7.7) | 3 (1.7) | 6 (2.8) | ||
| Metaplastic Subtype - n (%) | Matrix producing | 18 (46.2)* | |||
| Spindle | 14 (35.9) | ||||
| Squamous | 5 (12.8) | ||||
| Mixed spindle / matrix producing | 2 (5.1) |
*
Two of the 18 tumors were diagnosed as MpBC based on the post-NAT surgical specimen.