Table 4. TGA values in the diagnosis of celiac disease at different cut-off levels.
TGA: anti-transglutaminase antibody; PPV: positive predictive value
TGA cut-off value | Sensitivity, % | Specificity, % | PPV, % | |||
Value | 95% CI | Value | 95% CI | Value | 95% CI | |
21.74 U/mL | 100% | 94.64–100 | 99.0% | 96.47–99.88 | 97.1% | 89.40–99.25 |
29.42 U/mL | 100% | 94.64–100 | 99.5% | 97.27–99.99 | 98.5% | 90.46–99.79 |
39.69 U/mL | 95.5% | 87.47–99.07 | 100% | 98.19–100 | 100% | |
41.31 U/mL | 92.5% | 83.44–97.53 | 100% | 98.19–100 | 100% | |
TGA >10 and villous atrophy | ||||||
29.42 U/mL | 100% | 94.40–100 | 98% | 95.08–99.47 | 94.1% | 85.84–97.69 |
36.1 U/mL | 100% | 94.40–100 | 98.5% | 95.78–99.7 | 95.5% | 87.40–98.50 |
39.69 U/mL | 96.9% | 89.16–99.62 | 99% | 96.52–99.88 | 96.8% | 88.64–99.19 |
41.31 U/mL | 93.8% | 84.76–98.27 | 99% | 96.52–99.88 | 96.7% | 88.29–99.17 |
52.7 U/mL | 90.6% | 80.70–96.48 | 100% | 98.22–100 | 100% |