Table 4.

Selected clinical findings of Guillain Barré syndrome patients reported in VAERS following Adenovirus Type 4 and Type 7 Vaccine, Live, Oral, October 2011 through July 2018.

Case and Year	Age (Yr) Sex	Recent History of Illness	Vaccines	Onset after Adenovirus vaccination (days)	Diminished DTR	CSF	EMG and NCS	Diagnosis	Treatment	Brighton level
1 2011	24M	URTI/sinusitis	Adeno Hep A Hep B MMR Varicella (5 days prior IPV IIV MCV4)	31	√	2 wbc normal protein	Consistent with AIDP/GBS	GBS	IVIG	2
2 2011 OBS STUDY	19-24M	URTI	Adeno (24 days prior MCV4 Tdap IIV Hep A)	2	√	Normal	Consistent with GBS/AIDP	GBS	IVIG	2
3 2011 OBS STUDY	~22M	URTI (1-2 weeks prior to onset of weakness)	Adeno Hep A (5 days prior IIV Tdap MCV4 IPV)	31	√	Normal	Consistent with AIDP/GBS	GBS	IVIG	2
4 2012	18M	URTI	Adeno Hep A/Hep B MCV4 Tdap	9	√	Not done	Consistent with AIDP/GBS	GBS	IVIG Prednisolone	2
5 2012	27M	URTI (1 week prior to onset of weakness)	Adeno LAIV Tdap Hep A/Hep B MCV4 Varicella (35 days later Hep A/Hep B IPV Varicella)	42	√	1 wbc normal protein	No record	GBS	IVIG	3
6 2012	20M	URTI/sinusitis (2 weeks prior to onset of weakness)	Adeno IIV IPV MCV4 Tdap (1 day prior Hep B MMR Varicella and 6 days later Hep A)	32	√	2 wbc elevated protein	Inflammatory neuropathy	GBS	IVIG	1
7 2013	19F	None	Adeno Hep A/Hep B LAIV MCV4 Tdap	9	√	2483 rbc elevated protein (traumatic LP)	No record (discussed with neurology team)	GBS	IVIG	3
8 2014	28F	None	Adeno Tdap MCV4 IIV	19	√	0 wbc normal protein	Mild sensory neuropathy	Atypical GBS	IVIG	2
9 2014	25M	URTI	Adeno MCV4 Tdap	25	√	100 wbc† normal protein	AMSAN	GBS AMSAN	IVIG	2
10 2015	17M	URTI	Adeno LAIV MMR Tdap MCV4 (4 days later Varicella)	31	√	Not done	No record	GBS	IVIG	3
11 2015	22M	Bell’s palsy treated with prednisolone and valacyclovir	Adeno Hep A LAIV Varicella Tdap MCV4	15	Normal DTRs	0 wbc elevated protein	Mild axonal involvement	GBS	IVIG	1
12 2017	19M	Bell’s palsy treated with prednisolone	Adeno Tdap Varicella IPV Hep A/Hep B MCV4 IIV MMR	27	√	Hemolyzed specimen	Not done	Miller Fisher syndrome	Steroid taper	3

Abbreviations used in this table: Yr = year, DTR = deep tendon reflexes, CSF = cerebrospinal fluid, EMG and NCS = electromyogram and nerve conduction study, M = male, F = female, URTI = upper respiratory tract infection, Adeno = adenovirus vaccine, Hep A = hepatitis A vaccine, Hep B = hepatitis B vaccine, MMR = measles mumps and rubella vaccine, IPV = inactivated poliovirus vaccine, IIV = inactivated influenza vaccine, MCV4 = meningococcal conjugate vaccine, √ = diminished DTRs, wbc = white blood cell, AIDP = acute inflammatory demyelinating polyneuropathy, GBS = Guillain Barré syndrome, IVIG = intravenous immunoglobulin, OBS = patient included in observational study, Tdap = tetanus diphtheria attenuated pertussis vaccine, Hep A/Hep B = combined hepatitis A and B vaccine, LAIV = live attenuated influenza vaccine, LP = lumbar puncture, AMSAN = acute motor sensory axonal neuropathy.

^†Brighton criterion for cytoalbuminologic dissociation is CSF protein elevation above laboratory normal value and CSF total wbc count <50 cells/ul.