Table 2.
Laboratory indices of patients with COVID-19 versus H7N9 virus infection at admission
| Indices | COVID-19-ARDS (n = 66) | COVID-19-non-ARDS (n = 34) | P1 value | H7N9-ARDS (n = 32) | H7N9-non-ARDS (n = 14) | P2 value | Pa value |
|---|---|---|---|---|---|---|---|
| Blood counts | |||||||
| Leukocytosis | 31(47.0%) | 3(8.8%) | <0.001 | 5(15.6%) | 0(0%) | 0.293 | 0.003 |
| Leukopenia | 3(4.5%) | 3(8.8%) | 0.683 | 10(31.3%) | 8(57.1%) | 0.098 | 0.001 |
| Neutrophilia | 44(66.7%) | 9(26.5%) | <0.001 | 10(31.3%) | 2(14.3%) | 0.4 | 0.001 |
| Neutropenia | 1(1.5%) | 2(5.9%) | 0.553 | 3(9.4%) | 2(14.3%) | 1 | 0.194 |
| Lymphopenia | 57(86.4%) | 21(61.8%) | 0.002 | 30(93.8%) | 13(92.9%) | 1 | 0.586 |
| Thrombocytopenia | 21(31.8%) | 4(11.8%) | 0.028 | 14(43.8%) | 5(35.7%) | 0.611 | 0.248 |
| Anemia | 19(28.8%) | 6(17.6%) | 0.223 | 15(46.9%) | 5(35.7%) | 0.482 | 0.078 |
| Serum biochemistry | |||||||
| Albumin<30 g/L | 24(36.4%) | 3(8.8%) | 0.003 | 14(43.8%) | 4(28.6%) | 0.332 | 0.482 |
| Elevated TBIL | 10(15.2%) | 1(2.9%) | 0.131 | 2(6.3%) | 0(%) | 1 | 0.351 |
| Elevated ALT | 34(51.5%) | 10(29.4%) | 0.035 | 9(28.1%) | 6(42.9%) | 0.523 | 0.029 |
| Elevated AST | 40(60.6%) | 14(41.2%) | 0.065 | 26(81.3%) | 10(71.4%) | 0.723 | 0.041 |
| Elevated BUN | 28(42.4%) | 4(11.8%) | 0.002 | 20(62.5%) | 4(28.6%) | 0.034 | 0.062 |
| Elevated creatinine | 27(40.9%) | 10(29.4%) | 0.259 | 8(25%) | 5(35.7%) | 0.699 | 0.123 |
| Elevated LDH | 59(89.4%) | 25(73.5%) | 0.04 | 31(96.9%) | 13(92.9%) | 0.521 | 0.382 |
| Inflammatory markers | |||||||
| CRP: 10 times the ULN | 26(39.4%) | 3(8.8%) | 0.001 | 11(34.4%) | 5(35.7%) | 1 | 0.631 |
| PCT: 10 times the ULN | 16(24.2%) | 0(0%) | 0.002 | 4(12.5%) | 0(0%) | 0.415 | 0.176 |
| Coagulation condition | |||||||
| Elevated PT | 44(66.7%) | 6(17.6%) | <0.001 | 14(43.8%) | 2(14.3%) | 0.111 | 0.03 |
| Elevated APTT | 31(47.0%) | 15(44.1%) | 0.786 | 9(28.1%) | 2(14.3%) | 0.524 | 0.075 |
| Elevated Fib | 45(68.2%) | 30(88.2%) | 0.028 | 3(9.4%) | 0(0%) | 0.543 | <0.001 |
| Elevated D-dimer | 58(87.9%) | 23(67.6%) | 0.015 | 18(56.3%) | 6(42.9%) | 0.403 | <0.001 |
a
Comparison between COVID-19-ARDS and H7N9-ARDS
ARDS: acute respiratory distress syndrome; TBIL: total bilirubin; ALT: alanine aminotransferase; AST: aspartate aminotransferase; BUN: blood urea nitrogen; LDH: lactate dehydrogenase; CRP: C-reaction protein; PCT: procalcitonin; ULN: upper limit of normal; PT: prothrombin time; APTT: activated partial prothrombin time; Fib: fibrinogen.