Table 2.

Incidence rates and hazard ratios of cancer risk

Exposure of interest	Number of Events	Incidence Rate per 1,000 Person-years (95% CI)	Crude Hazard Ratio (95% CI)
Any type of cancer
General Population (reference)	485	9.96 (9.11–10.9)	1.00
Mutation-carrying HeFH relatives	30	11.3 (7.89–16.1)	1.18 (0.81–1.71)
Nonmutation-carrying HeFH relatives	12	4.81 (2.73–8.47)	0.45 (0.26–0.80)
Comparison of relatives^a	…	…	2.39 (1.24–4.61)
All-cause mortality
General Population (reference)	563	10.8 (9.98–11.8)	1.00
Mutation-carrying HeFH relatives	22	7.61 (5.01–11.6)	0.70 (0.46–1.07)
Nonmutation-carrying HeFH relatives	18	7.04 (4.44–11.2)	0.65 (0.40–1.03)
Comparison of relatives^a	…	…	1.08 (0.58–2.02)

CI Confidence Interval, HeFH Heterozygous Familial Hypercholesterolemia

^a Cox regression analyses comparing the two groups of relatives with nonmutation-carrying HeFH relatives as a reference