Table 2.

Antipsychotic medication use and mean medication possession ratio of the overall cohort during the pre-index and post-index periods

	Pre-index period (n = 1,211; 100%)		Post-index period (n = 1,211; 100%)		Mean difference [95% CI]
Received ≥ 1 dispensation, n (%)
Oral
First generation	130 (10.7%)		120 (9.9%)
Second generation	966 (79.8%)		841 (69.5%)
Long acting-injectable
First generation	192 (15.9%)		67 (5.5%)
Second generation	N/A (N/A)		1,211 (100%)
Medication possession ratio, mean (SD); mean difference [95%CI]
Overall	0.45 (0.40)		0.84 (0.26)		0.39 [0.36, 0.41]
Oral
First generation	0.03 (0.14)		0.03 (0.13)		-0.0046 [-0.014, 0.0043]
Second generation	0.40 (0.39)		0.38 (0.41)		-0.019 [-0.044, 0.0065]
Long acting-injectable
First generation	0.07 (0.20)		0.02 (0.11)		-0.05 [-0.060, -0.038]
Second generation	N/A (N/A)		0.64 (0.33)		N/A

Bolded mean difference indicates statistically significant difference (p < 0.001) between the 2-year post- and 2-year pre-index using paired t-tests. Abbreviations: CI Confidence interval, N/A Not applicable, SD standard deviation