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. 2022 Jul 2;23(1):75. doi: 10.1186/s10194-022-01442-8

Fig. 1.

Fig. 1

The experimental protocol of the study. (a) Schematic timeline diagram of drug treatment and behavioral assessment in mice. (b) Details of the dosing regimen for each group of mice. IS, 20μL/day for 4 days, dural injection; PBS, 20μL/day for 4 days, dural injection; BBG, a specific P2X7R antagonist, 50 mg/kg/day for 4 days, intraperitoneal injection; VEH, 0.9% saline, the same volume as BBG, intraperitoneal injection. Abbreviations: DS, dural stimulation; i.p., intraperitoneal injection; VFT, von Frey’s test; IS, inflammatory soup; PBS, phosphate buffer saline; BBG, brilliant blue G; VEH, vehicle