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. 2022 Jul 3;26:196. doi: 10.1186/s13054-022-04060-7

Table 1.

Demographic characteristics

Training cohort pa Validation cohort pa pb
NIV success N = 922 NIV failure N = 529 NIV success N = 400 NIV failure N = 328
Age, years 63 ± 16 64 ± 16 0.61 61 ± 17 61 ± 16 0.99  < 0.01
Male 593 (64.3%) 377 (71.3%)  < 0.01 273 (68.3%) 217 (66.2%) 0.58 0.85
SOFA score 4.6 ± 2.4 6.1 ± 3.0  < 0.01 4.9 ± 2.1 6.0 ± 2.8  < 0.01 0.03
Septic shock 67 (7.3%) 138 (26.1%)  < 0.01 14 (3.5%) 59 (18.0%)  < 0.01  < 0.01
Presence of COVID-19 4 (0.4%) 0 (0%) 0.30 17 (4.3%) 26 (7.9%) 0.04  < 0.01
ICU type
 Medical 450 (48.8%) 300 (56.7%)  < 0.01 179 (44.8%) 151 (46.0%) 0.77 0.19
 Surgical 145 (15.7%) 58 (11.0%) 0.01 58 (14.5%) 50 (15.2%) 0.83 0.60
 Mixed 327 (35.5%) 171 (32.3%) 0.23 163 (40.8%) 127 (38.7%) 0.60 0.01
Reason for NIV
 Pneumonia 363 (39.4%) 347 (65.6%)  < 0.01 230 (57.5%) 255 (77.7%)  < 0.01  < 0.01
 Nonpulmonary sepsis 113 (12.3%) 79 (14.9%) 0.15 29 (7.3%) 27 (8.2%) 0.68  < 0.01
 Pancreatitis 109 (11.8%) 32 (6.0%)  < 0.01 23 (5.8%) 8 (2.4%) 0.04  < 0.01
 CPE 131 (14.2%) 7 (1.3%)  < 0.01 40 (10.0%) 4 (1.2%)  < 0.01  < 0.01
 Cardiac problem other than CPE 58 (6.3%) 16 (3.0%)  < 0.01 11 (2.8%) 10 (3.0%) 0.83 0.02
 Pulmonary embolism 16 (1.7%) 10 (1.9%) 0.84 8 (2.0%) 3 (0.9%) 0.36 0.73
 Trauma 19 (2.1%) 5 (0.9%) 0.14 13 (3.3%) 5 (1.5%) 0.16 0.19
 Poison 8 (0.9%) 5 (0.9%)  > 0.99 3 (0.8%) 0 (0%) 0.26 0.29
 Postoperative respiratory failure 9 (1.0%) 3 (0.6%) 0.55 9 (2.3%) 3 (0.9%) 0.24 0.13
 Asthma 7 (0.8%) 0 (0%) 0.05 1 (0.3%) 0 (0%)  > 0.99 0.28
 Inhalation injury 4 (0.4%) 0 (0%) 0.30 1 (0.3%) 1 (0.3%)  > 0.99  > 0.99
 Other 85 (9.2%) 25 (4.7%)  < 0.01 32 (8.0%) 12 (3.7%) 0.02 0.22
Presence of ARDS
 Pulmonary ARDS 49 (5.3%) 102 (19.3%)  < 0.01 48 (12.0%) 78 (23.8%)  < 0.01  < 0.01
Extrapulmonary  ARDS 109 (11.8%) 51 (9.6%) 0.22 9 (2.3%) 8 (2.4%)  > 0.99  < 0.01
Underlying disease
 Hypertension 394 (42.7%) 193 (36.5%) 0.02 166 (41.5%) 102 (31.3%)  < 0.01 0.10
 Diabetes mellitus 261 (28.3%) 130 (24.6%) 0.13 91 (22.8%) 68 (20.7%) 0.53 0.01
 Chronic kidney disease 109 (11.8%) 41 (7.8%) 0.02 73 (18.3%) 41 (14.5%) 0.04  < 0.01
 Chronic liver disease 24 (2.6%) 22 (4.2%) 0.12 21 (5.3%) 23 (7.0%) 0.35  < 0.01
 Chronic heart disease 300 (32.5%) 109 (20.6%)  < 0.01 119 (29.8%) 84 (25.6%) 0.25 0.92
 Chronic lung disease 143 (15.5%) 69 (13.0%) 0.22 60 (15.0%) 40 (12.2%) 0.28 0.60
 Presence of immunosuppression 45 (4.9%) 72 (13.6%)  < 0.01 60 (15.0%) 81 (24.7%)  < 0.01  < 0.01
Variables collected before NIV
 GCS 14.8 ± 0.6 14.6 ± 1.0  < 0.01 14.4 ± 1.5 14.2 ± 2.2 0.07  < 0.01
 Heart rate, beats/min 114 ± 24 118 ± 24  < 0.01 106 ± 23 111 ± 23  < 0.01  < 0.01
 Respiratory rate, breaths/min 30 ± 7 33 ± 8  < 0.01 28 ± 6 30 ± 8  < 0.01  < 0.01
 Systolic blood pressure, mmHg 134 ± 27 129 ± 26  < 0.01 134 ± 24 128 ± 25  < 0.01 0.49
 Diastolic blood pressure, mmHg 78 ± 17 75 ± 17 0.02 78 ± 17 74 ± 15  < 0.01 0.52
 pH 7.42 ± 0.10 7.41 ± 0.12 0.11 7.43 ± 0.08 7.42 ± 0.10 0.04 0.11
 PaCO2, mmHg 33 ± 8 32 ± 8 0.01 34 ± 7 34 ± 8 0.67  < 0.01
 PaO2/FiO2, mmHg 178 ± 74 153 ± 60  < 0.01 147 ± 104 137 ± 85 0.16  < 0.01
 HACOR score 4.7 ± 2.7 6.4 ± 3.1  < 0.01 5.7 ± 3.1 6.9 ± 3.5  < 0.01  < 0.01
Variables collected after 1–2 h of NIV
 GCS 14.9 ± 0.4 14.5 ± 1.2  < 0.01 14.5 ± 1.5 14.2 ± 2.2 0.03  < 0.01
 Heart rate, beats/min 105 ± 22 112 ± 24  < 0.01 100 ± 21 107 ± 22  < 0.01  < 0.01
 Respiratory rate, breaths/min 26 ± 6 31 ± 8  < 0.01 25 ± 6 28 ± 8  < 0.01  < 0.01
 Systolic blood pressure, mmHg 129 ± 23 127 ± 25 0.19 128 ± 22 124 ± 22 0.01 0.05
 Diastolic blood pressure, mmHg 73 ± 14 71 ± 16 0.06 76 ± 15 73 ± 14 0.01  < 0.01
 pH 7.44 ± 0.07 7.40 ± 0.11  < 0.01 7.44 ± 0.06 7.42 ± 0.09 0.01 0.22
 PaCO2, mmHg 34 ± 7 34 ± 12 0.38 35 ± 7 35 ± 9 0.70 0.03
 PaO2/FiO2, mmHg 241 ± 108 168 ± 89  < 0.01 182 ± 67 140 ± 61  < 0.01  < 0.01
 HACOR score 2.5 ± 2.2 6.0 ± 3.6  < 0.01 3.9 ± 2.9 6.2 ± 3.5  < 0.01  < 0.01
De novo acute respiratory failure 508 (55.1%) 358 (69.6%)  < 0.01 233 (58.3%) 215 (65.5%)  < 0.05 0.93
Outcome
 Death in hospital 53 (5.7%) 256 (48.4%)  < 0.01 15 (3.8%) 153 (46.6%)  < 0.01 0.35
 Length of ICU stay, days 6 (4–10) 7 (3–13) 0.14 7 (5–12) 9 (4–16) 0.20  < 0.01
 Length of hospital stay, days 16 (10–26) 11 (5–22)  < 0.01 18 (11–28) 14 (6–24)  < 0.01 0.02

NIV  noninvasive ventilation, SOFA   sequential organ failure assessment, ICU  intensive care unit, CPE   cardiogenic pulmonary edema, ARDS  acute respiratory distress syndrome, GCS Glasgow Coma Scale, HACOR heart rate, acidosis, consciousness, oxygenation, and respiratory rate

ap for the difference between NIV success versus failure

bp for the difference between training cohort versus validation cohort