Table 2.
Critical Biologic Administration Information
| Asthma Biologic Therapy | Type of Injector | Region for Injection | Room Temperature-Time Recommendations | Biologic Expiration after Being at Room Temperature | Home Storage |
|---|---|---|---|---|---|
| Omalizumab43 | Prefilled Syringe | Front and middle of the thighs and the stomach area (abdomen). The outer area of the upper arms may also be used if a caregiver is giving the injection. | Set aside the carton for at least 15 to 30 minutes so the prefilled syringe can warm up on its own to room temperature. | The total combined time out of the refrigerator may not exceed 2 days. If the prefilled syringe is exposed to temperatures above 77 °F (25 °C), do not use it and throw it away in a sharps disposal container. | Store in the refrigerator between 36°F and 46°F (2°C to 8°C). |
| Mepolizumab44 | Autoinjector and Prefilled Syringe | Front and middle of the thighs and the stomach area (abdomen). The outer area of the upper arms may also be used if a caregiver is giving the injection. | Wait 30 minutes (and no more than 8 hours) before use. | If necessary, an unopened carton can be stored outside the refrigerator at up to 86°F (30°C) for up to 7 days. | Store in the refrigerator between 36°F to 46°F (2°C to 8°C). |
| Reslizumab45 | Not available for home administration | Intravenous, is given in a clinic or infusion center | N/a | N/a | N/a |
| Benralizumab46 | Autoinjector and Prefilled Syringe | Front and middle of the thighs and the stomach area (abdomen). The outer area of the upper arms may also be used if a caregiver is giving the injection. | Warm-up at room temperature between 68°F to 77°F (20°C to 25°C) for about 30 minutes before giving the injection | May be kept at room temperature between 68°F to 77°F (20°C to 25°C) for a maximum of 14 days. | Store in the refrigerator between 36°F to 46°F (2°C to 8°C). |
| Dupilumab47 | Autoinjector and Prefilled Syringe | Front and middle of the thighs and the stomach area (abdomen). The outer area of the upper arms may also be used if a caregiver is giving the injection. | Let it naturally warm to room temperature for at least 45 minutes. | It may be stored at room temperature up to 77°F (25°C) up to 14 days. | Store in the refrigerator between 36°F to 46°F (2°C to 8°C) |
| Tezepelumab48 | Prefilled Syringe | Front and middle of the thighs and the stomach area (abdomen). The outer area of the upper arms may also be used if a caregiver is giving the injection. | Allow it to reach room temperature. This generally takes 60 minutes. | May be kept at room temperature between 68°F to 77°F (20°C to 25°C) for a maximum of 30 days | Store in the refrigerator between 36°F to 46°F (2°C to 8°C). |
Abbreviations: F, Fahrenheit; C, celsisus.