Figure 3.

Treatment of SARS-CoV-2 Wuhan infection by antibodies 3B8, 3E6, 2B2, and 1C1 (5 mg/kg) in hamsters

(A) Study design. Hamsters were intranasally infected with SARS-CoV-2 on day 0 and received intraperitoneal mAb treatment (5 mg/kg) 24 h post infection. Animals were sacrificed at day 4 for analysis of lung and blood samples.

(B) Concentration (μg/mL) of the administered antibodies in serum at day 4 post infection (n = 6 per group). Animals without detectable mAb serum levels were excluded from the graphs in panel C-D-E.

(C) Viral RNA levels, expressed as log₁₀ RNA copies per mg of lung tissue, at day 4 post infection.

(D) Infectious viral loads, expressed as log₁₀ TCID₅₀ per mg lung tissue, at day 4 post infection.

(E) Cumulative severity score from H&E stained slides of lungs from hamsters, at day 4 post infection. Individual data with median values are shown. Dotted line represents the detection limit. Results are from one experiment. ∗ = p < 0.05; ∗∗ = p < 0.01 as determined via Mann-Whitney U test. See also Table S3.