Figure 4.

Treatment of SARS-CoV-2 beta infection by antibodies 3B8, 3E6, 2B2, and REGN-COV-2 (5 mg/kg) in hamsters

(A) Concentration (μg/mL) of the administered antibodies at day 4 post infection in serum from hamsters (n = 6 per group) infected with SARS-CoV-2 beta.

(B) Viral RNA levels, expressed as log₁₀ RNA copies per mg of lung tissue, at day 4 post infection.

(C) Infectious viral loads, expressed as log₁₀ TCID₅₀ per mg lung tissue, at day 4 post infection.

(D) Cumulative severity score from H&E stained slides of lungs from hamsters, at day 4 post infection. Animals without detectable antibody serum levels were excluded from the graphs in panel B-C-D. Individual data and median values are shown. Dotted line represents the detection limit. Results are from one experiment. ∗ = p < 0.05; ∗∗ = p < 0.01 as determined via Mann-Whitney U test. See also Table S3.