Figure 6.

Dose-response experiment for treatment of SARS-CoV-2 delta infection with mAb 3B8 (5, 1, 0.2, or 0.04 mg/kg) in hamsters

(A) Concentration (μg/mL) of the administered antibodies in serum at day 4 post infection (n = 6 per group).

(B) Viral RNA levels, expressed as log₁₀ RNA copies per mg of lung tissue, at day 4 post infection.

(C) Infectious viral loads, expressed as log₁₀ TCID₅₀ per mg lung tissue, at day 4 post infection.

(D) Cumulative severity score from H&E stained slides of lungs from hamsters, at day 4 post infection, see also Figure S3. Individual data and median values are shown. Dotted line represents the detection limit. Results are from one experiment. ∗∗ = p < 0.01 as determined via Mann-Whitney U test.