Figure 7.

Pharmacokinetics and efficacy of intramuscular DNA-encoded 3B8 delivery for protection against SARS-CoV-2 delta infection in hamsters

(A) Study design. 600 μg p3B8 was delivered via intramuscular electroporation at either 10, 7 or 5 days prior to infection (n = 6 per group). Animals of the negative control group were left untreated. Concentration (μg/mL) of 3B8 in serum at day 0 (B) and 4 (C) post infection.

(D) Viral RNA levels, expressed as log₁₀ RNA copies per mg of lung tissue, at day 4 post infection.

(E) Infectious viral loads, expressed as log₁₀ TCID₅₀ per mg lung tissue, at day 4 post infection.

(F) Cumulative severity score from H&E stained slides of lungs from hamsters, at day 4 post infection. Individual data and median values are shown. Dotted line represents the detection limit. Results are from one experiment. ∗ = p < 0.05; ∗∗ = p < 0.01 as determined via Mann-Whitney U test.